Vitamins
Vitamin D, 1,25-Dihydroxy
Also known as: Calcitriol, 1,25(OH)2D, 1,25-Dihydroxyvitamin D
CONVERT & COMPARE
pg/mL
=
119
pmol/L
=
49.6
ng/L
Reference ranges by source
Published adult intervals: 5, from 4 named sources, shown in pg/mL.
SOURCE
SEX
AGE
RANGE
VISUAL
CITE
About Vitamin D, 1,25-Dihydroxy
A vitamin D test measures the levels of vitamin D in your blood. Vitamin D helps your body absorb calcium to build healthy bones and teeth. It also helps keep your muscles, nerves, and immune system working normally. Having vitamin D deficiency (low levels of vitamin D) can lead to bone disorders and other medical conditions.
Before your body can use vitamin D, your liver must change it into another form called 25 hydroxyvitamin D, also known as 25(OH)D. Most vitamin D blood tests measure the level of 25(OH)D in your blood, because it is the most accurate way to measure how much vitamin D is in your body.
Another type of vitamin D test measures "active vitamin D," which is also called calcitriol or 1,25-dihydroxyvitamin D. This test isn't usually used to check whether you are getting enough vitamin D, but it may be used to monitor people with certain kidney problems or abnormal blood calcium levels.
Main source: MedlinePlus ↗
Useful for
Help evaluate causes of abnormal blood calcium levels.
Help monitor people with certain kidney problems.
Main source: MedlinePlus ↗
Interpretation
Your provider will interpret 1,25-dihydroxyvitamin D results in the context of your symptoms, calcium levels, and kidney function.
Low levels are most often seen in chronic kidney failure (because diseased kidneys can't make enough active vitamin D) and in hypoparathyroidism.
High levels can be seen in primary hyperparathyroidism, in some granulomatous diseases such as sarcoidosis, in tuberculosis, and in some lymphomas, where the body makes too much active vitamin D outside of normal control.
1,25-dihydroxyvitamin D is not a reliable way to check for vitamin D toxicity from supplements; for that, the standard 25-hydroxyvitamin D test is used.
If you have questions about what your results mean, talk with your provider.
For general wellness information only. Talk to a clinician about your specific results.
Main source: MedlinePlus ↗
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Related biomarkers
More tests in the vitamins category.
Sources
Last updated 2026-05-02
This page presents source-specific reference data and sourced explanations. For general wellness information only. This is not medical advice. For diagnosis or treatment of any condition, talk to a qualified clinician.